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2019年09月19日 15:10:25
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Oncology and genetics肿瘤遗传学Grabbing cancer by the short and curlies短发卡——钳住癌症的新武器A new technique for analysing tumours promises better understanding and more effective treatment一项研究肿瘤的新技术为人类更加深入地了解肿瘤并找到更加有效的治疗方法带来了希望 Sep 24th 2011 | SAN FRANCISCO | from the print editionONE of the great hopes nurtured by the Human Genome Project was that it would crack cancer open. Knowing which genes were going wrong would, the theory went, allow specifically tailored drugs to be developed. And this is, indeed, happening. Only last month America’s Food and Drug Administration approved a medicine called Xalkori (generically, crizotinib) for patients who have a particular type of non-small-cell lung cancer, the most common form of that disease. Xalkori blocks the growth of tumours caused by a mutant form of the gene which encodes a signalling molecule known as anaplastic lymphoma kinase. This mutation occurs in 3-5% of lung-cancer patients, and in trials Xalkori caused a dramatic shrinkage of the tumour in around half of those treated.找到克癌症的方法,是人类基因组计划带给人们最大的希望之一。理论上,只要找到出错的基因,就能研发出针对它的特定药物。事实上,这些期望正在被逐步实现。就在上个月美国食品药品批准了一种名为Xalkori(通用名:克里唑蒂尼)的新药上市,用于治疗非小细胞肺癌(最常见的一种肺癌)。Xalkori能够抑制由编码信号分子间变性淋巴瘤激酶基因的突变体所导致的癌细胞的增长。3-5%的肺癌患者体内存在这种突变。临床试验中,大约一半受试者在过此药后体内癌细胞数量显著减少。The catch is that the respite does not last. Typically, someone will respond for about a year, but after that his tumour starts growing again and the disease continues on its course. This is a pattern seen again and again with the new generation of drugs that genomics has helped to create. They slow the disease, but only for a few months. The presumption is that further mutations are arising in a tumour all the time, and that eventually one of them makes a molecular change that nullifies the effect of the drug. Researchers would dearly like to find a way to deal with this.但问题是Xalkori对病情的缓解作用持续时间不长。一般来说,持续药一年后患者将产生抗药性,体内癌细胞恢复增长导致病情恶化。这是一代代利用基因组学开发出的药物共同的治疗效果变化模式,最终都只能短暂地缓解病情。其机制可能是,癌细胞会不断地产生新的突变体,最终其中的某个突变体编码产生了使药物作用失效的蛋白分子。研究人员正致力于找出对付这种机制的办法。201109/155609青岛地区市市立医院打玻尿酸多少钱Huawei华为Interesting ing有料A Chinese industrial champion opens up a bit on its way to world domination一家中国工业引领者走向全球的道路上,撩开了一点自己的面纱Apr 20th 2011 | HONG KONG | from the print editionANOTHER annual report sent out in the season when countless companies worldwide are publishing them is at risk of being filed in the bin. Not so if the company is Huawei and the report is intended to make a company that reflects the best of China’s manufacturing prowess, while being a prime example of its secretiveness, seem normal.值全球无数公司发表年度报告之季,又会有年报可能被扔进垃圾桶。不过,倘若是华为,倘若年报意在让这家显示中国最出色制造实力——而充当保密先锋——的公司看似平常,则另当其说。The telecoms-equipment maker’s financial performance is impressive enough to make the report worth ing: revenues were 185 billion yuan (.4 billion), having grown by an annual average of 29% in the past four years. The growth rate for profits has been 56%. Having just passed Nokia and Siemens, Huawei looks on track to overtake Ericsson, the industry leader, this year.这家电信设备制造商财务状况让人惊叹,报告值得一读:年营收1850亿元(274亿美元),四年年平均增长率达29%。利润增长率56%。刚刚赶超诺基亚和西门子的华为,似乎今年就有望追上行业老大爱立信。But it faces some big impediments, perhaps the most important being the concerns of many governments, notably America’s and India’s, about a private company suspected of links to the security apparatus of a country said to be conducting sophisticated hacking. Because of such worries, Huawei’s efforts to buy American companies have been blocked and some sales have been lost.但华为也面临几重阻碍,其中最严重的,可能是以美国和印度为代表的许多政府都担心,一家私企可能与中国安全机构有牵连,而中国据称又在实施精密的黑客攻击。因为上述担忧,华为希望购买几家美国公司都遭到拒绝,一些生意也随之东流。201108/147964山东省青岛莱阳玻尿酸多少钱Infidelity faces women with greater incomeMen who earn less than their female partners are more likely to cheat on them, a study published on Monday found.Cheating may be a man's way of trying to restore his gender identity when he feels it is under threat, Christin Munsch, a sociology doctoral candidate at Cornell University, says in the study, which she authored and presented at the annual meeting of the American Sociological Association."Making less money than a female partner may threaten men's gender identity by calling into question the traditional notion of men as bwinners," Munsch said.Indeed, the study found that infidelity dramatically increased when the man earning less than his female partner is Latino, probably because bwinner status is "one of the defining features of Hispanic masculinity."Then again, the same study found that men whose partners were more dependent on them were also more likely to cheat, making it a lose-lose situation for women.It's different for girls, though. Overall, women are half as likely to cheat as men anyway, whatever the circumstances, the study found."Women's femininity is not defined by their bwinner status, nor is it defined by sexual conquest. Therefore, economic dependency does not serve as a threat to women," Munsch says.The study indicates ways to prevent one's partner cheating without giving up the well-paid day job. Both sides being satisfied in a relationship is a sure-fire way to make infidelity disappear, and getting your partner to go to church or the mosque or temple regularly is another: the more regularly an individual attends a religious service, the less likely he or she is to cheat, the study says.Looking for a partner in a university library, lab or lecture might also be an idea because, the study says, "the more education one reports, the less likely he or she is to engage in infidelity."Vocabulary:doctoral candidate:士生call into question: 使……受到质疑sure-fire:准不会有错的背单词 — 装英语词汇201008/111664Just as the Internet's social networks have changed the way people communicate - a case in point is how Facebook helped Egyptian protesters to organize their historic demonstrations - social media also are changing the way doctors' offices operate and the way patients communicate with their doctors.互联网中的社交网络改变了人们的交流方式,社交媒体也在改变医生诊所的运作以及病人和医生交流的方式。What if you could use your cell phone to go online and make your medical appointments, request prescription refills or ask your doctor a question? Or, if you could retrieve your medical records wherever you had Internet access? What if an emergency room doctor could instantly see your health records, the medications you are taking and communicate with your doctor? It could save time, and maybe even your life. This is how social media and technology are changing the way medicine is practiced. 如果你可以用手机上网预约看病时间,请医生开处方,或者问医生问题;或者,如果你能在任何可以上网的地方察看你的病历;或者,如果急诊室里的医生能够立刻看到你的病历和用药记录,并且和你的医生取得联系,你觉得怎么样?那样不仅能够节省时间,甚至挽救你的生命。这就是社交媒体和技术如何在改变医疗运作的方式。Dr. Jeff Livingston's practice, MacArthur Ob/Gyn in Irving, Texas, does all of this. "It has just revolutionized the way we do healthcare," he said.德克萨斯州艾尔文市麦克阿瑟妇产科医院的杰弗·利文斯顿医生,就是这样做的。利文斯顿说:“这使我们提供医疗务的方式发生了革命性的改变。”Livingston and his colleagues use social media and password-protected software to share medical information with their patients. "We provide the patient full access to their medical care. Anything I can see, the patient can see. All of their notes, all of their doctor visits are right there. All of their lab work is right there."利文斯顿医生和同事们利用社交媒体和有密码保护的软件,和他们的病人交流相关信息。利文斯顿医生说:“我们让病人完全了解有关他们治疗的情况。任何我能看到的东西,病人也能看到。他们所有的陈诉,医生门诊的所有记录都在这里。所有化验报告也都在这里。”Patients can communicate privately with their doctors on the practice's web site through a secure connection or "portal" - and they can get information or join forums on the practice's social media sites. 病人可以透过安全的网站门户,在医生的网站上与医生交流。他们也可以在社交媒体网站上获得有关资讯,听取其他人的意见。"We want to engage our patients in their healthcare," said Livingston. "So our practice has a Facebook page. It has a MySpace page. We have a Twitter feed. We have thousands of people who follow us through all this media. And what we found is that the patients really love that."利文斯顿说:“我们希望病人参与自己的医疗保健。因此,我们有一个脸书网页,一个聚友网页,还有推特。数以千计的人透过这些媒体了解我们的资讯。我们发现,病人真的喜欢这种交流方式。”Kristi Francisco said she likes being able to log on and get the results of her medical tests. "This way I could get right into the practice portal and see, yes, everything’s fine and I don’t have to worry about things and just go on with my day and get on with my life." 克里斯蒂·弗朗西斯科说,她喜欢上网查阅她的检查报告,“我可以直接进入医生的网站,看见一切检查结果都正常,我就放心了。”201103/127659青岛鼻子打玻尿酸多少钱

青岛城阳人民医院洗牙价格青岛诺德医学美容医院怎么样Report: N. Korean Leader Signals Possible Return to Nuclear Talks北韩释放愿重返六方会谈信号North Korea's leader has apparently told a senior Chinese envoy he is willing to resume talks to resolve the issue of Pyongyang's nuclear weapons.北韩领导人据报对中国高级特使表示,他愿意返回有关解决北韩核武器计划的会谈。China's Xinhua news agency says North Korean leader Kim Jong Il promises to work toward making the Korean peninsula free of nuclear weapons. Mr. Kim also is willing to engage in what the report describes as "bilateral or multilateral talks" to help push that goal forward.中国官方的新华社说,北韩领导人金正日允诺为实现朝鲜半岛无核化而努力。报道还说,金正日还愿意参加朝这一目标努力的“双边或多边会谈”。Those comments, if accurate, would be the first explicit sign in months that North Korea is willing to resume diplomacy aimed at ending its nuclear weapons programs. Mr. Kim reportedly made them to senior Chinese envoys visiting Pyongyang.如果报道属实,这将是数月以来北韩第一次明确表示愿意重新参加旨在终止北韩核计划的外交努力。据报道,金正日向访问平壤的中国特使做出这个表示。A North Korean state broadcaster says Mr. Kim met with Dai Bingguo, an envoy of Chinese Premier Hu Jintao. They held talks in a "cordial atmosphere" about continuing the North Korea-China friendship.北韩国家广播电台说,金正日会见了中国总理温家宝的特使戴秉国,在“亲切气氛中”讨论了北韩和中国继续发展友谊的问题。China's envoy to six-nation nuclear talks, Wu Dawei, also attended the meeting. The often-stalled six-nation talks also involve the ed States, South Korea, Japan, and Russia. Earlier this year, North Korea declared the six-party process "useless" and over with. It conducted its second nuclear test in May.六方会谈的中国代表团团长武大伟也参加了会见。参加有关北韩核计划的六方会谈的还有美国、韩国、日本和俄罗斯。六方会谈经常搁浅。今年早些时候,北韩宣称六方会谈“毫无用处”,将不再参加。北韩5月进行了它的第二次核试验。South Korean officials caution against interpreting Mr. Kim's reported comments as a signal the North is y to come back to the talks. The South's foreign minister, Yu Myung-hwan, told business leaders in Seoul Friday that Pyongyang has other ideas.韩国官员说,不应急于把报道提及的金正日讲话视为北韩将重返六方会谈的信号。韩国外交通商部长柳明桓星期五在首尔对商界领袖说,平壤另有想法。Yu says now that North Korea possesses nuclear weapons, Pyongyang intends to have U.S.-North Korea arms reduction talks, which the U.S. cannot accept. 柳明桓说,北韩现在已经拥有核武器,打算和美国进行削减军备的谈判,而美国不会接受这个要求。Washington has ruled out such arms reduction talks, which would implicitly recognize North Korea as a nuclear weapons state. The ed States and its regional partners say they will accept nothing less than a complete and verifiable end to North Korea's nuclear arms capabilities. 美国排除了与北韩进行削减军备谈判的任何可能。进行这种谈判将等于明确承认北韩是核国家。美国及其东亚盟友说,必须以可核查的方式全面废止北韩的核武器能力,除此之外不接受任何其它方案。President Obama's administration has expressed willingness to talk to North Korea one-on-one, but only in a context that is directly connected to the six-party talks.奥巴马政府表示愿意与北韩进行一对一的谈判,但条件是这种谈判必须直接相关六方会谈。North Korea analysts here in the South Korean capital find it significant that Mr. Kim's reported comments come during a visit from China. Beijing is the North's only significant ally, and provides a lifeline of food, fuel, and resources to its hobbled economy.首尔的北韩问题分析人士认为,在中国特使访问北韩之际报道金正日的这个讲话具有重大意义。Hong Hyun-ik is a North Korea researcher at the Sejong Institute in Seoul.韩信一是首尔世宗研究所的北韩问题研究员。He says China felt the need to stop the North's nuclear activities from getting out of hand. He says Beijing also does not want to be isolated from any one-on-one diplomatic arrangement between North Korea and the ed States. So, China sent its envoy, says Hong, to remind Kim Jong Il how crucial it is to the North's economic fate.他说,中国感到有必要制止北韩的核活动,以防事态失控。他说,北京不希望被排斥在北韩和美国任何一对一谈判之外,因此派遣特使提醒金正日,中国对北韩经济具有至关重要的作用。09/84603Matilda Cuomo - wife, mother, teacher and former first lady of New York State - has perhaps had the most far-reaching impact as founder of Mentoring USA, which has trained volunteer mentors for more than 5,000 schoolchildren nationwide.玛蒂尔达.科莫夫人是母亲,是教师,是前纽约州的第一夫人,也是“美国辅导教育计划”的创办人。这项组织到目前为止,为全美国五千名学童训练志工导师。Cuomo was born in Brooklyn, New York, in 1931, during the Great Depression. Despite the bleak economic conditions, her mother, an Italian immigrant, and her father, the child of immigrants, were intent on realizing the American dream for themselves and their five children. 1931年美国经济大萧条期间,玛蒂尔达.科莫在纽约市布鲁克林区出生。尽管他们那时面临着严峻的经济情况,她的母亲,一名来自意大利的移民,以及她的父亲,一名移民之子,都决心要使他们的美国梦,实现在他们两人和五名子女的身上。"I was very fortunate in that regard. They suffered and struggled and sacrificed so much," she says . "They put five children through college without a Pell Grant or government help. You have to honor them for that and appreciate it and be gratified. So that’s how I feel." 玛蒂尔达.科莫说:“在这一方面,我非常幸运。他俩承受了困难,并且做出很多奋斗和牺牲。他们靠着贝尔助学金和政府的协助,将我们五名子女都送进大学。我们真该为此向他们表示敬意,感受他们为我们所做的。”Doing whatever is necessary to make life better has been a recurring theme in Cuomo’s life - as a teacher, a mother and a mentor. In 1954, she married a young law student named Mario Cuomo whose long public service career eventually led to the New York State governor’s mansion. 作为教师,母亲和导师,玛蒂尔达.科莫一生经常持有的理念,是做一切该做的,使生活变得更好。1954年,她和一名年轻的律师马里奥.科莫结为夫妇。马里奥长年参与公共事物,终于成为纽约州长。Looking out for childrenAfter that election in 1982, Cuomo also entered public service as a volunteer advocate for children. 在1982年的选举之后,玛蒂尔达.科莫也加入了公共事物的领域。她成为促进儿童福利的志愿人员。The mid-1980s were a difficult time for New York State. The economy was in recession. Crack addiction was becoming epidemic in the cities. The teen pregnancy rate was soaring, and the high school graduation rate was plummeting to record lows. These trends were deeply disturbing to Governor Cuomo. 1980年代中期对纽约来说,是一个困难的时期。不仅是经济上的不景气,各大城市都有毒品泛滥的问题。少女怀率上升。同时,高中学生的毕业率下降。这些趋势使科莫夫妇深感困扰。201106/140302山东省青岛聊城激光去痣一般多少钱Can China cushion the blow?China's surging economy may be able to cushion the blow from a slowdown in the U.S. CNN's John Vause reports.Like so many of China’s growing middle class, Pan Honglin is cashed up and y to spend, he wants to buy this fully-loaded SUV, price tag including taxes,45,000 US dollars. But he will have to wait, the salesman told me I can’t have it for more than 3 months, he says, there are orders for this car until April. Chinese consumers wealthier than ever are spending more than ever, helping to drive this economy like never before. For five years now, the economy has been growing at double-digit speed, so fast the government has struggled to slow it. So a drop in demand from the US, China’s No1 customer for exports would be seen here as not necessarily a bad thing. It would tone down Chinese trade surplus a bit, it would tone down inflationary pressures a bit and it would tone down overall growth a bit. Many exporters are feeling the pinch like this Beijing textile company, manager Yang Aiwu tells me her sales to the US are down but she adds "we’re doing better business with Europe, Russia and Australia", some economists argue China is now so robust that a drop in US exports won’t have a major impact at all. ”The thing is what we’ve seen in recent years is significantly growth not all the way, by any means been driven by exports it’s been domestic demand, It's been consumption and investment Investment in all those things China didn’t build for 50 years. Roads, airports and skyscrapers, lots of skyscrapers. in recent years an estimated 40 billion US dollars has been spent rebuilding Beijing alone.In fact, some economists now argue that China’s economy is so big and getting bigger, that while it may not be able to save the world from a US-led recession, Chances are it will soften the blow. John Vause, CNN, Beijing.02/62943青岛隆鼻费用

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