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明星资讯腾讯娱乐2019年07月18日 01:26:25
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Now from the Boston Museum of Science, Sci-tech today on NECN.有线新闻,波士顿消息,欢迎收看今天的Sci-tech Today。There are so much in the news about flu vaccines these days, how exactly do they work? Joining us now from the Museum of Science Boston is Anita Loughlin from the Boston University School of Medicine, good to have you here.最近有许多关于流感疫苗的消息,疫苗究竟是如何预防疾病的?今天来自波士顿大学医学院的Anita Loughlin将向我们做详细介绍。你好。Thank you, nice to be here.谢谢,很高兴参加这期节目。Why do people need to get immunized? What is the history of immunization in this country?为什么人类需要免疫系统?美国的免疫史是怎样的?The prevention of vaccine-preventable diseases/serious diseases has been the number one accomplishment of vaccines in the 20th century. Weve therefore controlled small pox, weve um... eradicated polio from the Americans, we controlled diseases like measles,tetanus, diphtheria, and news diseases that were controlling now are things like hemophilus influenzae, which caused a lot of meningitis, 20,000 cases each year as early as 1990. We vaccinate people for two reasons, one, to keep the individual healthy, and the second reason is, if we vaccinate more people, there is actually barriers and so that we can actually prevent the sp of disease in the community, thats called herd immunity. And we do that, so that we can prevent people that are at high risk for complications.通过疫苗来防御疾病,尤其是严重疾病是20世纪最伟大的成就。我们现在消除了小儿麻痹症,控制了天花,麻疹,破伤风,白喉等疾病,最近还控制了能引起髓膜炎的嗜血杆菌流感,自1990年以来,控制病例达20,000之多。人类打疫苗有两个原因,第一,是为了个人的身体健康,第二,是为了防止疾病传播,这叫做群体免疫。这么做,我们就能降低人类得病的机率。What can you tell us about the H1N1 vaccine and the reasons for having two vaccines this year?你能告诉我们H1N1流感疫苗的情况吗?为什么今年会有两只流感疫苗?Well, the reason for having two vaccines this year is, well, every year we actually make a new seasonal flu vaccine, the strain of seasonal flu that circulates every year changes a little bit by what is called antigenic drift, and so every year there is a global surveillance, and the manufacturers have to look and see what strain is circulating, and they put those strains into the vaccine, the best match those that are circulating, so every year we make a new flu vaccine. The H1N1 strain started circulating a little bit later than we could do it to get it into the annual this flu vaccine, so they actually made a new vaccine. Now they made that vaccine in exact same way they made the seasonal flu vaccine, they use the exact same equipment, the exact same manufactures, the exact same testing procedures.为什么今年会有两只流感疫苗呢,事实上,每年我们在研制疫苗的时候,会发现每年当季传染病的主要病毒会稍有不同,学名称作“抗原漂移”,所以每年我们都会调查当季的病毒,工厂也需要调查主要病毒,将病毒加入疫苗中,病毒每年都在循环变化,所以我们每年都在制作新的疫苗。现在,他们研制疫苗的方式正是我们当初研制疫苗的方式,他们和我们使用的是同样的设备,同样的工艺,同样的程序。Does the HPV vaccine works the same way that the flu vaccines work?疫苗和病毒发挥作用的原理一样吗?They all work in a similar way in a sense that our body is producing antibodies to prevent either the attachment of the virus to ourselves or to, be able to remove that virus more quickly from our body in preventing affection.疫苗和病毒发挥作用的原理是相同的,疫苗是通过刺激机体产生抗体来防御病毒或更快地从人体中移除病毒来预防病毒。And is that only for females?只需要向女性注射疫苗吗?No, the reason why the HPV virus is actually sp, is that they were targeting in sp by sexual transmission, so you are right, if we want to, to sp , prevent to sp it in poplulation, we would give it to both males and females. The reason why women and girls are in targeted, it is because cervical cancer is the number two cause of cancer in the ed States, causing about ten thousand new cases per year, and about three thousand thirty seven hundred death per year. And the prevention of cervical cancer is the reason why its been targeted towards women. Now In the new vaccines, they also prevent other HPVs, once they cause genital warts and papillomas of respiratory track and papillamas in the respiratory track of young children born into women with genital warts. Those vaccines are 90% affective, are preventing these genital warts and these other things. And they also seems to be affective and preventing other genital cancers and heading that cancers that affect both men and women, so now in just recently Otocber , the gardasil vaccine has been licensed and recommended for boys and young men.不,HPV病毒传播的途径是性传染途径,如果想防止HPV病毒传播,就要向男性和女性都注射疫苗。主要向女性宣传,是因为宫颈癌是美国第二大癌症,每年造成1万女性患病,三万三千七百女性死亡。宫颈癌病发在女性也是原因之一。一旦病毒造成妇生殖器疣和呼吸道乳头状瘤,新型疫苗可以预防HPV病毒感染腹中胎儿。疫苗能90%有效地防止生殖器疣等病发症,预防男性和女性感染病毒。年10月,疫苗经过批准使用,收到了青年男士女士的青睐。All righty, Doctor, Anita Loughlin of the Boston University School of Medicine, thanks for joining us.好的,感谢波士顿大学医学院的士Anita Loughlin的精介绍。small pox: 天花polio: n. 小儿麻痹症,脊髓灰质炎measle: n. [动]囊尾蚴tetanus: n. 破伤风diphtheria: n. 白喉hemophilus: 嗜血杆菌meningitis: n. 髓膜炎herd immunity: 群体免疫,人群免疫antigenic drift: 抗原性漂移cervical cancer: 子宫颈癌papilloma: n. 乳头肿genital: n. 生殖器wart:n. 疣,瘿respiratory track: 呼吸道注:本篇文章英文来自普特论坛,译文属原创,,。201206/185799

  Science and technology.科技。Malaria,Not swatted yet.消灭疟疾任重道远。A new vaccine is one step towards a distant goal.一种新疫苗让人类离消灭疟疾更近了一步。MAN has vanquished only one disease, smallpox. In 2007 Bill Gates set out to eradicate another, malaria. The World Health Organisation (WHO) was soon rallying its troops to the cause and a flood of money followed. 2m went to research in alone. This week the Bill amp; Melinda Gates Foundation trumpeted another announcement: results from a phase III trial (the more extensive process of testing drugs in people) of a malaria vaccine called RTS,S. This is the worlds most advanced vaccine for malaria and the results, published in the New England Journal of Medicine, were encouraging.到目前为止人类只消灭了天花这一种疾病。2007年,比尔?盖茨宣布开始着手消灭另一种疾病即疟疾。世界卫生组织迅速召集队伍致力于这项事业,并在随后投入大量资金,年仅在研究上就投入了6.12亿美元。本周,;比尔和梅琳达?盖茨基金会;发表了另一个声明,内容是世界上对抗疟疾最先进的疫苗RTS,S的第三试验阶段(在人群中广泛使用药物并测量反应)的结果,发表于《新英格兰医学杂志》上的结果振奋人心。It is an important step in combating a disease that still kills more than 700,000 people a year and debilitates millions more. But it is also a reminder of how much work remains to be done.每年因疟疾致死的人有700000人,致残的有 数百万人,这个试验结果是战胜这一疾病的重大进步。但是它也提醒人们还有多少任务尚未完成。Mr Gates is only malarias latest adversary. The parasite has plagued man for millennia. Chinese texts from 2700 describe plants to treat its fevers. More recently, in 1955, the WHO embarked on its first malaria-eradication effort. But transmission rates in Africa seemed intractable. After 14 years the WHO gave up. The last time the world tried to eliminate malaria, some scientists lament, the world eliminated malariologists.疟疾祸害人类千年,盖茨先生最近一个反抗它的对手。公元前2700年中国的文字资料就记载着一些植物能治疗由疟疾引起的发烧的。再往离现在近的时间看,世界卫生组织在1955年展开首次消灭疟疾的行动。但是在非洲,遏制疟疾的传播率似乎非常棘手。14年之后,世卫放弃了。有些科学家慨叹,上一次世界本来试图消灭疟疾,结果被消灭的是疟疾学家。The new wave of enthusiasm came with the founding of the Roll Back Malaria Partnership in 1998 (to co-ordinate planning), the PATH Malaria Vaccine Initiative in 1999 (with money from the Gates Foundation) and the ed Nations Global Fund to Fight AIDS, Tuberculosis and Malaria in 2002. This culminated in Mr Gatess call to arms four years ago and has helped to lower the number of malaria deaths by 20% over the past decade.随着1998年;遏制疟疾伙伴关系;(共同测绘)、1999年;疟疾疫苗开发计划;(资金来自盖茨基金会)和2002年联合国全球治疗艾滋病肺结核和疟疾基金的建立,对抗疟疾的新一轮热潮出现了。四年后盖茨振臂一呼,在十年里疟疾死亡率降低了20%,推动抗疟疾的热潮达到顶峰。More progress will be difficult. The existing tools of insecticide-treated bed nets and treatment drugs require careful co-ordination and good health systems. Eliminating malaria in a stable country is dramatically easier than doing so in a turbulent one. Worryingly, these tools may become less effective. Parasites in South-East Asia, for example, seem to be developing resistance to artemisinin-based treatments. To achieve eradication-or anything close to it-new weapons are needed.要想获得更多进展非常困难。现有的带有杀虫剂蚊帐和药物治疗要求配合细致和良好的医疗系统。在一个政局稳定的国家消灭疟疾比在政局动荡的国家更容易。比如,东南亚的寄生虫似乎对基于青蒿素的治疗起了抗药性。要想消灭疟疾——或是向这个目标再迈进一大步—就得发展新武器。RTS,S, developed by GlaxoSmithKline (GSK), a British pharmaceutical company, will help. The vaccine tries to stop one type of malaria parasite, Plasmodium falciparum, before it has a chance to wreak havoc. A mosquitos bite delivers malaria to the body. Travelling swiftly to the liver, the parasites hide, mature and multiply before staging a grand second act in the bloodstream, where they invade red blood cells, multiply again, and invade more cells. RTS,S combines a circumsporozoite protein, which exists on the parasites surface, with a protein from a hepatitis B vaccine. Together, these trigger an immune response which can fight off invading parasites before the second act.这个新武器就是由英国制药公司葛兰素史克公司(GlaxoSmithKline研制的RTS,S。该疫苗能停止疟疾寄生虫恶性疟原虫的活性,使它不能为非作歹。蚊子叮一口就会把疟疾传到人身上。它传播敏捷,在寄主身上隐藏起来、成熟、繁殖,然后在血液里进行第二个大的行动,入侵红细胞后再次繁殖,接着侵占更多细胞。RTS,S把存在于寄生虫表面的环子孢子蛋白和肝炎B型疫苗里的一种蛋白结合在一起。它们共同作用引发一种免疫反应,在第二次活动前就击退入侵的寄生虫。GSK tested the vaccine in 6,000 infants across sub-Saharan Africa. It reduced the risk of clinical malaria by 56% and severe malaria by 47%. This efficacy was ;on the positive side of what we were expecting,; says Christian Loucq of the PATH Malaria Vaccine Initiative, GSKs partner on RTS,S.葛兰素史克公司在撒哈拉以南非洲的6000名婴儿身上测试了这种疫苗。患临床疟疾的风险减少了56%,患严重疟疾的风险减少了47%。葛兰素史克公司在研制RTS.S的搭档;疟疾疫苗开发计划;的Christian Loucq说这种效力;是我们曾期待的积极一面;。However, more is to come. The trial examined children aged 5-17 months. Results for younger babies will follow. Still uncertain is how long the vaccines protection lasts. The first year that the vaccine might be used would be 2015, and that is if everything goes as planned. Even then, it is unclear how RTS,S might be deployed. Its price is uncertain and its power limited. ;We realise that RTS,S is not the ultimate malaria vaccine,; says David Brandling-Bennett of the Gates Foundation. ;But it will have some role. The challenge is figuring out what that role is.;然而,更多的试验紧随其后。上面提到的试验测试对象是5-17个月大的婴儿。随后会出炉年龄更小婴儿的结果。这种疫苗的保护能持续多久还不清楚。疫苗投入使用可能会从2015年开始,前提是如果一切按计划进行的话。即使到那时候,还不清楚RTS.S会怎样投放。价格不定,效力也是有限的。;我们认识到RTS.S并非是最好的疟疾疫苗,;盖茨基金会的大卫?布兰丁-内特这样说,;但是它会起到一些作用。我们的挑战是研究出这种作用是什么。;Researchers are aly working on the next generation of vaccines. GSK hopes to induce a stronger immune response by combining RTS,S with a vaccine from Crucell, another drug firm. Scientists are also keen to develop vaccines that target different kinds of malaria parasites and in different ways-for example, in mosquitoes guts. All of this work requires further investment at a time when global health programmes must compete fiercely for cash. Mr Gates has helped to spur progress. Sustaining it is the next challenge.研究者已经开始从事下一代疫苗的开发。葛兰素史克公司希望使用RTS,S和另一家制药公司Crucell的一种疫苗的结合体来引起更强烈的免疫反应。科学家也努力研制针对不同种类疟疾寄生虫和不同感染途径——比如,在蚊子的内脏里——的疫苗。这些工作都需要继续投入资金,而现在正是全球医疗项目必须为资金激烈竞争的时候。盖茨先生已经为推动研究进步做出贡献。如何保持这种势头是下一个挑战。 /201208/196129

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  Its Thursday, June 30th, 2011. Im Wilson Tang on Cnet.com and its time to get loaded.今天是2011年6月30日,周四。我是Cnet.com的Wilson Tang。是时间接收本周的最新资讯了。As we reported yesterday, MySpace is up for sale and it looks like its found a buyer in Specific media. As a part of 35 million dollar deal, News Corporation will take a minority stake in Specific Media, and half of MySpaces 400 personnel Staff will be cut. Although better than the 30 million dollars we reported yesterday, its still a far cry from the 100 million dollars. And News Corp won it, and a huge loss for the 580 million dollars the company spent to buy the social network at the first place.我们昨天报道过Myspace正在进行出售,买家有可能是Specific Media。Myspace售价高达3500万,MySpace将拥有Specific Media的少量股权,并且Myspace将裁员400人。虽然收购价格比昨天报道的300万还高,但这和Myspace预计的1亿美元有很大差距。Myspace的东家是新闻集团,这笔成交价比当初新闻集团收购Myspace 这一社交网络的5亿800万价位低了许多。Ironically, Justin Timberbrake who played Shawn Parker in the social network Facebook movie is an investor in Specific media.具有讽刺意味的是,在《社交网络》中扮演主角肖恩·帕克的演员贾斯汀·汀布莱克正是Specific media的投资人之一。The HP touch pad will be officially released tomorrow. And here at Cnet we got our hands on a review unit. Rather than use the Google Android operating system, the new touchpad runs Palms WebOS. In addition, the touchpad runs adobe flash has support for bits audio enhancements and an impressive third party calendar messaging and email services. Otherwise, CNet editors pointed out that the touchpad is much thicker than the ipad2, doesnt record HD vedio and has a limited latch of third party apps. Pricing starts at 9 for the 16 gigabyte version. Check out our more extensive view at CNet.com惠普的全触控平板电脑TouchPad将于明天正式发售。我们的Cnet将带你一起回顾。惠普的TouchPad没有采用谷歌安卓运行系统,而是运行Palm的WebOS系统。另外,这款TouchPad运行adobe flash,持全部格式影音播放,日历提醒,邮件务等功能。另外,Cnet的编辑指出TouchPad比iPad2纤薄许多,不能录制高清视频,限制部分第三方应用。16G的TouchPad售价499美元。更多信息尽在Cnet.com。Skype has announced that its app for Android will now have vedio conversing support. Skype for Android2.0 will be able to place and receive vedio calls with owners of Android handsets as well as iPhone, Mac, Windows PC and other Skype platforms. Calls can be placed over both wifi and 3G. In addition to the vedio chatting feature, Skype for Android 2.0 has a brand new design with a new mood message box so you can let your contacts know how youre feeling or what you up to. Skype for Android 2.0 vedio chatting feature only works for the HDC Desire S, Sony Exon Xspirial Pro, and Google Nexus S phones with more coming in the near future.Skype宣布其安卓应用将持视频通话。适用于安卓2.0的Skype应用可接受来自安卓手机,iPhone,Mac,Windows PC和其他设备的视频通话。通话可使用Wifi或是3G网络。除了视频通话功能,Skype安卓2.0版应用还新设计了一个情绪信息功能,这样你的联系人就能通过它来了解你的心情或是最新消息。Skype安卓2.0版的新功能现在还只适用于HDC Desire S,索尼Exon Xspirial Pro和谷歌的Nexus S手机,未来这款应用将会适用于更多手机。In response to the negative massive outcry to Final Cult Pro X, Apple has released a FAQ that answers some questions but confirms the fears of some professional vedio editors. First the bad news, Final Cult Pro X will not have the ability to open Final Cult Pro Ⅷ projects. And the good news, Apple says its committed to releasing an XML and XS tool and support for multi-cam editing soon. In general, the company wants its usuers to know it hears and understands the concerns but also wants Final Cult Pro X to embrace a new editing philosophy.为回应对Final Cult Pro X的消极抗议,苹果公司发布了FAQ以解答用户的部分问题,并肯定了部分专业视频编辑的担心。坏消息是,Final Cult Pro X将不能打开Final Cult Pro Ⅷ。好消息是苹果下定决心发布XML和XS工具持multi-cam编辑。总地来说,苹果公司是希望用户了解并理解他们的考虑和顾虑,同时苹果公司还希望Final Cult Pro X能改进编辑方式。Hackers have been in the news a lot these days. Mostly for attacking corportations and governements, and releasing private information but it looks like they maybe doing some good in the world as well. N news reports that hackers have temporarily shut down Al-Quaidas online distribution of vedios and statements, so far no one has claimed credit for the attack.最近的新闻中常能听到黑客的消息。大多数的消息都是黑客攻击了公司或政府网络系统,公布大量个人信息,但于此同时他们也做了件好事。N新闻报道黑客暂时关闭了Al-Quaida的在线视频网站,目前还没有组织承认对此次网络攻击负责。Those are your headlines for today. Im Wilson Tang for Cnet.com, and youve just been loaded.以上就是今天的头条,我是Cnet.com的Wilson Tang。感谢您的收看。注:本篇文章英文来自普特论坛,译文属原创,,。201211/211049

  Finance and Economics;Microfinance in India;Road to redemption;The industry is starting to revive;财经;印度的小额贷款;救赎之路;小额信贷蓄势再发;IndiaS microfinance sector was once touted as a saviour of the poor and a good bet for investors. The high point for the industry came when SKS—then Indias biggest microfinance company with a .2 billion loan book, a third of it in the southern state of Andhra Pradesh—went public in July 2010. The 0m offering was more than 13 times oversubscribed.小额信贷在印度曾一度被吹捧为是穷人的救世主,投资者的好选择。当时印度最大的小额信贷公司SKS以12亿美元的放贷额将这一行业推向了高潮,其中三分之一的贷款流向了南部州安得拉邦。该公司在2010年7月上市时,价值3亿5000万美元的新股被超额认购13倍多。Things went downhill fast. Many in the industry admit that runaway growth spurred reckless lending to poor Indians. Just months after the SKS listing, Andhra Pradeshs state government accused the industry of strong-arm collection tactics that drove some farmers to suicide. It issued suffocating rules; almost all loans in the state were written off; business ground to a halt. But the industry is starting to revive, with regulators in a far more central role.然而这一形式却急转直下。很多业内人士承认小额信贷的疯狂发展刺激公司把钱轻率地借给穷人。SKS上市几个月后,安得拉邦州政府便控诉信贷业中的暴力收账迫使一些农民自杀。州政府随后下发了遏制条例,使得该州几乎所有小额贷款都被当做坏账核销,当地商业活动也被迫停顿了下来。但现在小额信贷业又将蓄势再发,不过这次管理人员担当着更为核心的角色。Microlenders are attracting capital again. Grameen Capital India, a social-investment bank, says 4m of equity has been injected into microfinance groups in the past 12 months, more than double the amount in the preceding year. The International Finance Corporation, a multilateral lender, invested m in Equitas, a mid-sized group in the southern state of Tamil Nadu. SKS, whose loan book is now worth just 5m, raised .5m by issuing shares last year.眼下小额放贷公司又在吸引着投资者。印度乡村资本是一家社会投资,该行表示过去一年里已经将1.44亿美元的股本注入小额信贷集团,相比头一年要高出一倍多。多边放贷人国际金融公司将1800万美元的资金投入到了泰米尔纳德邦一家名为Equitas的中型信贷集团。SKS目前的放贷总额仅有3.25亿美元,其去年增发的新股筹集了4750万美元。Outside Andhra Pradesh microlenders loan books rose in value by 33% year on year in the third quarter of 2012, according to the Microfinance Institutions Network (MFIN), an industry body. Southern states and the eastern state of West Bengal are new hotspots. Bandhan, a no-frills company based in West Bengal, now has over 4m borrowers and the largest microfinance loan book in the country. Analysts say the sectors outstanding loans are now worth billion-3 billion, compared with a peak of around billion during the boom.小额信贷机构网(MFIN)的数据显示,2012年第三季度里,邦外的信贷公司流向安得拉邦的贷款比去年同期上涨了33%。南方各邦以及东部的孟加拉邦是新的热点投资地带。孟加拉邦的基本务公司班丹目前已经为400多万人提供过贷款,人数上在印度排名第一。分析师说目前小额信贷的未偿还贷款约为20到30亿美元,而繁荣期时的峰值约为50亿美元。Indias central bank is behind the renewed confidence. It released national guidelines for microlenders at the end of 2011 and has set up a licensing system. Although a bill officially appointing the central bank as the industrys regulator is languishing in parliament, these moves have helped stem what M.R. Rao, the boss of SKS, calls a “fear of contagion”, the worry that other states will copy Andhra Pradesh and suddenly draw up new rules.印度中央是促成小额信贷复苏的主要原因。2011年年末,中央就小额信贷公司出台了国家指导方针,并建成了许可制度。虽然对议会来说,将中央指定为这一行业的管者的法案令人难以接受,但这些措施却帮助阻止了SKS老总所说的“蔓延恐惧”,即担心其它各邦会效仿安得拉邦,也突然起草新规定。The guidelines try to draw a line between profits and profiteering. Microlenders annual interest rates are now capped at 10-12 percentage points above their own borrowing costs, leaving most charging 23-27%. Some charged 40% during the boom; dodgy local loan-sharks, the only alternative source of credit in many rural areas, have even higher rates. Microlenders are also barred from lending to anyone with more than one outstanding loan.指导方针试图划清盈利和暴利之间的界限,规定小额信贷公司的贷款年利率与其成本利率之间的最高差额要在10到12个百分点之间,这使得大部分贷款利率处在23%-27%之间。信贷繁荣时期的年利率有时高达40%,而在很多农村地区,奸诈的高利贷主作为唯一的信贷来源收取的利率甚至比这还要高。方针还禁止小额信贷公司贷款给任何有一笔及以上未偿还贷款的人。But capping profits may end up harming the neediest borrowers, say lenders. Undertaking small transactions in remote areas is not cheap. Chandra Shekhar Ghosh, Bandhans managing director, says he keeps costs down with one-room branches containing little more than plastic chairs. Alok Prasad, the head of MFIN, warns that others may ditch the hardest-to-reach villages.但是信贷公司表示限定利率最终可能会伤害到最贫困的借款人群。在偏远地区承办小额交易的成本很高。班丹公司总经理钱德拉-谢卡尔 高希说,为了节约开,他们的分行只占用一个房间,里面只有几个塑料凳。MFIN的总裁阿洛卡-普拉萨德警告道,要是其他的信贷机构,可能就会放弃那些最难抵达的村落。Some microfinance firms are looking beyond small, unsecured loans, which the central bank caps at 50,000 rupees (0) a pop. Equitas last year set up a subsidiary that sells mortgages to poorer customers. Bandhan has similar plans. P.N. Vasudevan, the managing director of Equitas, says his housing loans, starting at 100,000 rupees, involve lower operating costs, in part because mortgage payments often get transferred via banks and do not require collection. If firms start to gravitate towards these lines of business, that could yet again leave the neediest behind.央行还规定抵押贷款一次不能超过50,000卢布(910美元),但一些小额信贷公司的眼光却没有停留这种小额无担保贷款上。Equitas去年成立了一个子公司,专门为较为贫困的客户提供抵押贷款。班丹公司也有类似的计划。Equitas的总经理P.N.瓦苏德万说他们公司的房贷门槛是100,000卢布,营业成本相对较低,部分原因是按揭付款通常是通过转账,不需要亲自去收账。如果小额信贷公司把重心向这些业务转移,最贫困的人群将再次被甩在后面。 /201301/221192

  

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